Supramolecular Chemistry Team (CS)

Research activity

The supramolecular chemistry team’s research activities are in the field of sustainable chemistry, at the interface of two disciplines: organic synthesis and supramolecular chemistry. They contribute to the development of more environmentally friendly chemical processes by developing unconventional synthesis methods (ultrasound, microwave),as well as methods for encapsulating bioactive compounds, remediation and detection of organic and inorganic pollutants, in the context of biomass recovery.

Supramolecular chemistry:

Since the applications associated with cage molecules largely depend on the stability of the complexes formed with the substrates, understanding the mechanisms involved in recognition is essential for the design of new compounds and is therefore a major focus of our academic research. In this context, we are developing innovative characterisation methods (optical and NMR spectroscopies, headspace, isothermal titration microcalorimetry). These studies are carried out in aqueous solutions, but also in mixtures with low melting points, such as deep eutectic solvents (DES). We are formulating new solvents with supramolecular properties, either by dissolving cyclodextrins in DES or by obtaining DES directly from cyclodextrins.

The supramolecular edifices formed in this way have two main applications:

  • Remediation and detection of organic and inorganic pollutants

One of the main limitations of the remediation processes currently available is the low solubility of hydrophobic organic compounds in water. Our research involves developing innovative methods adapted to hydrophobic organic compounds (VOCs, POPs, etc.) and based on the complexation and solubilisation properties of cyclodextrins or biobased solvents.

  • Encapsulation of compounds of interest (aromas, essential oils, active ingredients)

Encapsulation is a technique used to enclose liquids or solids in an envelope. Cyclodextrins can be used to protect active ingredients against physical and chemical degradation, or to enable controlled or prolonged release of active ingredients. Our work involves characterising the complexes formed in solution (UV-visible, headspace, ITC, NMR) or in the solid phase (DSC, IR) and studying the effect of encapsulation on the physicochemical and/or biological properties of the guest.

Enhancing biomass

In addition to the use of bio-based compounds in our supramolecular formulations, we are developing a research theme dedicated to the development, from products derived from flax (fibre, mucilage), of a base of bio-based compounds (resins, adhesives, binders) for the formulation of new materials. It is part of a partnership with the regional flax industry. With a view to possible industrial applications, semi-pilot sonochemical reactors are being developed to produce high-quality fibres and to functionalise biomass.

Team members

Scientific collaborations

Nationals :

  • Unité de Dynamique et Structure des Matériaux Moléculaire (UDSMM), University of Littoral Cote d’Opale (ULCO), Dunkerque
  • Unité de Catalyse et Chimie du solide (UCCS Artois), UMR CNRS 8181, University of Artois, Lens.
  • Unité des Matériaux et Transformations (UMET), UMR 8207, University of Lille, Villeneuve d’Ascq.
  • Glycochimie, Antimicrobiens et des Agroressources Laboratory, University of Picardie Jules Vernes, Amiens.
  • Institut Galien Paris-Sud (UMR CNRS 8612), University of Paris-Saclay.
  • Institut Lavoisier de Versailles, University of Versailles-Saint Quentin, Versailles.
  • Laboratoire de Chimie, ENS Lyon.
  • Laboratoire de Chimie de la Matière Complexe, UMR 7140, Institut Le Bel, University of Strasbourg.
  • Laboratoire Chrono-environnement, UMR 6249, University of Bourgogne-Franche-Comté, Besançon.

Internationals :

  • Section of Chemistry, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Danemark
  • Dipartimento di Chimica, Materiali ed Ingegneria Chimica « G. Natta, Politecnico di Milano, Italie
  • Bioactive Molecules Research Group, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Liban
  • Lebanese National Council for Scientific Research (CNRS-L), Lebanon
  • Istituto Struttura della Materia, Consiglio Nazionale delle Ricerche, Rome, Italie
  • Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
  • QUILL Research Centre, School of Chemistry and Chemical Engineering, Queen’s University Belfast, UK
  • Department of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic
  • Laboratoire de Photochimie et d’Analyse, Université Cheikh Anta Diop de Dakar, Sénégal.

Current thesis

Name

Period

Title

Mamadou Barry

2022-2025

Synthesis and characterisation of new MXene derivatives for energy storage and conversion

Sarah Karnib

2022-2025

Study of radionuclide chelation in aquatic environments using functionalized Calix[4]pyrrole supramolecular matrices

Gauthier Decool

2022-2025

Development of innovative formulations of natural biocides”, CIFRE Xéda International thesis.

Abbas Ahmad Kassem

2023-2026

New process based on bio-based solvents and compact absorbers for biogas purification”, Hauts-de-France Region, TIGA, Starklab

Simon-Lumière Divassa

2023-2026

Development of new biosourced matrices for 3D printing based on flax co-products.

Research agreement

  • 2023-2027 : ANR CDeePL « Biocompatible Porous Liquids based on Cyclodextrin-MOFs and eutectic solvents », sponsor.
  • 2023-2027 : ANR NanoBAP « Multifunctional Nanostructured Bio-based Active Food Packaging with antimicrobial properties », partner.
  • 2023-2025 : New process based on organic solvents and compact absorbers for purifying biogas (BIO2GAZ), CPER Ecrin.
  • 2023-2024 : PHC Orchid 49619UF, Determination of Total Vapor Pressure of Hydrophobic Deep Eutectic Solvents (DESs) and Conventional Green Solvents.
  • 2020-2026 : H2020-MSCA-RISE-2019 n°873005 : Waste Oils RecycLe and Development (WORLD).
  • 2020-2024 : Purification of biogas by absorption as part of the project » Dunkerque, l’Energie Créative « , supported by the CUD and winner of the Territoires d’Innovation (TI) action.
  • 2020-2024 : ADEME GRAINE contract « DEPHYTOP » Demonstrator for the phytomanagement of soil contaminated by TMEs based on the circular economy: Optimisation of the essential oils sector.

Recent publications

  • DANJOU P.-E., BILLET S., CAZIER-DENNIN F., BOUHSINA S., Large Interactive Touchscreens as an Opportunity for Synchronous Hybrid Teaching during the COVID-19 Pandemic and Beyond. Journal of Chemical Education, 2023, 100 (3), pp.1149-1154. ⟨10.1021/acs.jchemed.2c00833⟩⟨hal-03983386⟩
  • TRIOLO A., LO CELSO F., FOURMENTIN S., RUSSINA O., Liquid Structure Scenario of the Archetypal Supramolecular Deep Eutectic Solvent: Heptakis(2,6-di- O -methyl)-β-cyclodextrin/levulinic Acid. ACS Sustainable Chemistry & Engineering, 2023, 11 (24), pp.9103-9110. ⟨10.1021/acssuschemeng.3c01858⟩⟨hal-04142961⟩
  • BERLADEAN I., EPURE E.-L., IONICA CIOBANU C., CARLESCU I., BOUSSOUALEM Y., DANJOU P.-E., BHAT V., DUPONCHEL B., HURDUC N., DAOUDI A., Novel antiferroelectric materials with resorcinol-based symmetrical fluorinated bent-core mesogens. Journal of Molecular Liquids, 2023, 388, pp.122753. ⟨10.1016/j.molliq.2023.122753⟩⟨hal-04184856⟩
  • PIGNIER V., TOUMIEUX S., DAVOISNE C., CAROFF M., JAMALI A., PILARD S., MATHIRON D., CAILLEU D., BECUWE M., DELATTRE F., DOUALI R., SINGH D. P., Toward Conductive Additive Free Organic Electrode for Lithium‐Ion Battery Using Supramolecular Columnar Organization. Small, 2023, pp.2305701. ⟨10.1002/smll.202305701⟩⟨hal-04214106⟩
  • BEN ABADA M., SOLTANI A., TAHRI M., HAOUAL HAMDI S., BOUSHIH E., GREIGE-GERGES H., MEDIOUNI BEN JEMAA J., FOURMENTIN S., Encapsulation of Rosmarinus officinalis essential oil and of its main components in cyclodextrin: application to the control of the date moth Ectomyelois ceratoniae (Pyralidae). Pest Management Science, 2023, 79 (7), pp.2433-2442. ⟨10.1002/ps.7418⟩⟨hal-04242241⟩
  • EL HAJJ Z., CALANCEA S., HAOUAS M., LANDY D., NAOUFAL D., FLOQUET S., Playing with the Chaotropic Effect to Improve the Encapsulation of Decaborate Clusters within Cyclodextrins. Journal of Cluster Science, 2023⟨10.1007/s10876-023-02468-x⟩⟨hal-04180590⟩
  • BUI H., DELATTRE F., LEVACHER D., Experimental Methods to Evaluate the Carbonation Degree in Concrete-State of the Art Review. Applied Sciences, 2023, 13 (4), pp.2533. ⟨10.3390/app13042533⟩⟨hal-04290105⟩
  • PELUSO P., LANDY D., NAKHLE L., DALLOCCHIO R., DESSI A., KRAIT S., SALGADO A., CHANKVETADZE B., SCRIBA G. K., Isothermal titration calorimetry and molecular modeling study of the complex formation of daclatasvir by γ-cyclodextrin and trimethyl-β-cyclodextrin. Carbohydrate Polymers, 2023, 313, pp.120870. ⟨10.1016/j.carbpol.2023.120870⟩⟨hal-04320638⟩
  • KASPROWIAK A., RATHER I. A., ALI R., DANJOU P.-E., Revisiting β-dicyanovinyl substituted calix[4]pyrrole: Toward the chemodosimetric detection of hydrazine in solution. Journal of Molecular Structure, 2023, 1287, pp.135694. ⟨10.1016/j.molstruc.2023.135694⟩⟨hal-04210185⟩
  • NASR G., GREIGE-GERGES H., FOURMENTIN S., ELAISSARI A., KHREICH N., Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration. Beilstein Journal of Organic Chemistry, 2023, 19, pp.1570-1579. ⟨10.3762/bjoc.19.115⟩⟨hal-04252977⟩
  • ZAIDI M., BAILLIS D., NAOUAR N., DELATTRE F., DEPRIESTER M., Thermal Conductivity and Microstructure of Novel Flaxseed-Gum-Filled Epoxy Resin Biocomposite: Analytical Models and X-ray Computed Tomography. Materials, 2023, 16 (18), pp.6318. ⟨10.3390/ma16186318⟩⟨hal-04213221⟩
  • GREIGE-GERGES H., GERGES P., LICHTFOUSE J., LICHTFOUSE E., FOURMENTIN S. Wastewater technology attenuates the toxicity of shisha smoking. Environmental Chemistry Letters, 2023, 21 (2), pp.627-632. ⟨10.1007/s10311-022-01463-4⟩⟨hal-04043271⟩
  • NAKHLE L., KFOURY M., MALLARD I., GREIGE-GERGES H., LANDY D., Cyclodextrin polymers in combination with water and deep eutectic solvent for the retention of Eucalyptus citriodora essential oil. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2022, 102 (11-12), pp.831-840. ⟨10.1007/s10847-022-01161-2⟩⟨hal-04320648⟩
  • NAKHLE L., KFOURY M., MALLARD I., GREIGE-GERGES H., LANDY D., Solubilization of Eucalyptus citriodora essential oil and citronellal in deep eutectic solvents:water:cyclodextrins mixtures. Journal of Molecular Liquids, 2022, 359, pp.119371. ⟨10.1016/j.molliq.2022.119371⟩⟨hal-04320446⟩
  • PANDA S., FOURMENTIN S., Cyclodextrin-based supramolecular low melting mixtures: efficient absorbents for volatile organic compounds abatement. Environmental Science and Pollution Research, 2022, 29 (1), pp.264-270. ⟨10.1007/s11356-021-16279-y⟩⟨hal-04242270⟩
  • PETITPREZ J., LEGRAND F.-X., TAMS C., PIPKIN J., ANTLE V., FOURMENTIN S., KFOURY M., Huge solubility increase of poorly water-soluble pharmaceuticals by sulfobutylether-β-cyclodextrin complexation in a low-melting mixture. Environmental Chemistry Letters, 2022, 20 (3), pp.1561-1568. ⟨10.1007/s10311-022-01415-y⟩⟨hal-04242262⟩
  • EL MASRI S., RUELLAN S., ZAKHOUR M., AUEZOVA L., FOURMENTIN S., Cyclodextrin-based low melting mixtures as a solubilizing vehicle: Application to non-steroidal anti-inflammatory drugs. Journal of Molecular Liquids, 2022, 353, pp.118827. ⟨10.1016/j.molliq.2022.118827⟩⟨hal-04001031⟩
  • VILLARIM P., GENTY E., ZEMMOURI J., FOURMENTIN S., Deep eutectic solvents and conventional solvents as VOC absorbents for biogas upgrading: A comparative study, Chem. Eng. J., 446, 136875, 2022. DOI:10.1016/j.cej.2022.136875. ⟨hal-04242256⟩
  • GREIGE-GERGES H., GERGES P., LICHTFOUSE J., LICHTFOUSE E., FOURMENTIN S., Wastewater technology attenuates the toxicity of shisha smoking, Environ. Chem. Lett., 2022. DOI:10.1007/s10311-022-01463-4. 
  • PALAGYI A., JINDřICH J., DIAN J., FOURMENTIN S., Cyclodextrin-based Schiff base pro-fragrances: Synthesis and release studies. Beilstein Journal of Organic Chemistry, 2022, 18, pp.1346-1354. ⟨10.3762/bjoc.18.140⟩⟨hal-04242254⟩
  • THIARE D. D., DIAW P. A., MBAYE O. M. A., SARR D., GAYE-SEYE M. D., RUELLAN S., GIAMARCHI P., COLY A., AARON J.-J., DELATTRE F., Photodegradation study of the fenvalerate insecticide by 1H NMR, 13C NMR, and GC-MS and structural elucidation of its transformation products. Macedonian Journal of Chemistry and Chemical Engineering, 2022, 41 (2), pp.193-208. ⟨10.20450/MJCCE.2022.2571⟩⟨hal-04321127⟩
  • NAKHLE L., KFOURY M., GREIGE-GERGES H., LANDY D., Retention of a plethora of essential oils and aromas in deep eutectic solvent:water:cyclodextrin mixtures. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2022, 103 (1-2), pp.35-44. ⟨10.1007/s10847-022-01174-x⟩⟨hal-04320643⟩
  • ATTAR A. E., CHAKER H., DJENNAS M., FOURMENTIN S., Chemometric study in plasmonic photocatalytic efficiency of gold nanoparticles loaded mesoporous TiO2 for mineralization of ibuprofen pharmaceutical pollutant: Box Behnken Design conception. Inorganic Chemistry Communications, 2022, 146, pp.110210. ⟨10.1016/j.inoche.2022.110210⟩⟨hal-04242247⟩