The supramolecular chemistry team’s research activities are in the field of sustainable chemistry, at the interface of two disciplines: organic synthesis and supramolecular chemistry. They contribute to the development of more environmentally friendly chemical processes by developing unconventional synthesis methods (ultrasound, microwave) as well as methods for detecting or remedying pollutants and encapsulating bioactive compounds.
Moreover, since the applications associated with cage molecules are largely conditioned by the stability of the complexes formed with the substrates, understanding the mechanisms involved during recognition is essential for the “design” of new compounds and is therefore a strong focus of our academic research. In this framework, we develop innovative characterization methods (optical and NMR spectroscopy, headspace, isothermal titration microcalorimetry), which we confront with the simulation of complexes by molecular mechanics and quantum mechanics.
The application of the supramolecular buildings thus formed is then carried out along two main axes:
Remediation and detection of organic and inorganic pollutants
Among the remediation processes currently available, one of the main limitations remains the low solubility of hydrophobic organic compounds in water. Our research work consists in developing innovative methods adapted to hydrophobic organic compounds (VOC, POP…) and based on the complexing and solubilization properties of cyclodextrins or biosourced solvents.
New organic and/or hybrid materials are obtained by combining fluorescent cage molecules and silicic matrices and, with the aim of trapping and detecting gaseous pollutants (VOC) or metallic cations such as Fe(III). The development of these structures requires, among other things, sol-gel processes, particularly for the production of organized silica.
Encapsulation of compounds of interest (aromas, essential oils, active ingredients)
Encapsulation is a technique to trap liquids or solids in an envelope. Cyclodextrins can thus protect active ingredients against physical degradation, chemical degradation or to allow controlled or prolonged release of active ingredients. Our work consists in characterizing the complexes thus formed in solution (UV-visible, headspace, ITC, NMR) or in solid phase (DSC, IR) and in studying the effect of encapsulation on the physicochemical and/or biological properties of the guest.
Our sonochemical synthesis expertise has been put to good use in an emerging area:
Valorisation of biomass
This research theme aims to develop, from products derived from Linen (fibre, mucilage), a base of biosourced compounds (resins, adhesives, binders) for the formulation of new materials. It is part of a partnership with the Lin regional sector. With a view to possible industrial upgrading, semi-pilot sonochemical reactors are being developed for the production of high-quality fibres and the functionalization of biomass.
- Unité de Catalyse et Chimie du solide (UCCS Artois), UMR CNRS 8181, Université d’Artois, Lens.
- Unité des Matériaux et Transformations (UMET), UMR 8207, Université de Lille 1, Villeneuve d’Ascq.
- Groupe de Recherche Interdisciplinaire Innovation et Optimisation Thérapeutique (EA 4481), Lille 2.
- Institut Galien Paris-Sud (UMR CNRS 8612), Université Paris-Sud.
- Laboratoire de chimie, ENS Lyon.
- Chimie, Structures, Propriétés de Biomatériaux et d’Agents Thérapeutiques, UMR CNRS 7244, Université Paris 13.
- Institut de Chimie Séparative de Marcoule (ICSM), UMR CEA/CNRS/UM/ENSCM 5237, Equipe Systèmes HYbrides pour la Séparation (LHYS).
- Institut des Sciences de l’Évolution Montpellier (ISEM), équipe Evolution vecteurs adaptation et symbiose, Université Montpellier 2.
- Organische Makromolekulare Chemie, Universitaet des Saarlandes, Allemagne.
- Section of Chemistry, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Danemark
- Dipartimento di Chimica, Materiali ed Ingegneria Chimica « G. Natta, Politecnico di Milano, Italie
- Department of Chemical and Food Engineering, Université Vasile Alecsandri, Roumanie.
- Department of Applied Chemistry, Organic and Natural Compounds Engineering Polytechnic, Université de Timisoara, Roumanie
- Bioactive Molecules Research Group, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Liban
- Laboratoire de Photochimie et d’Analyse, Université Cheikh Anta Diop de Dakar, Sénégal.
Encapsulation of bioactive principles by modified cyclodextrins in deep eutectic mixtures
Elaboration and characterization of flax-based biocomposites with improved fire behaviour
|Sarah El Masri|
Vectorization of bioactive compounds in deep eutectic solvents: study of their solubility and bioavailability
Application of sonochemistry to the valorisation of flax shives into clean energy
New compact systems for biogas purification
- 2020-2024 : ” Dunkerque, l’Energie Créative “,
- project, winning project of the Territoires d’innovation (TI) action under the PIA.
- 2020-2023 : H2020-MSCA-RISE-2019 n°873005: Waste Oils RecycLe and Development (WORLD). 5 academic partners (France, Italy, Spain, Algeria) and 2 industrial partners (Italy, Spain). Project led by the Polytechnic Institute of Milan, Pr Andrea Mele.
- 2020-2022 : PHC Utique 44209NB project : Development of an innovative control strategy for the integrated management of food pests. Project in partnership with Pr Mediouni Ben Jemâa Jouda , INRAT, Tunis.
- 2020-2021 : FILAXTEXUS project : Production of textile flax fibres for open-end spinning by ultrasonic process and green sizing, public-private partnership the companies VRF and Textiles de Dunes. ADEME Graine.
- 2019-2021 : ScreEnDex project : Screening of Dextrin Encapsulation capabilities / Application to gaseous pollutants and pharmaceutical molecules, public-private partnership with the company Roquette Frères within the framework of the CPER IRENE.
- 2019-2021 : PCSI project : « Natural antimicrobials and insecticides encapsulated in biodegradable materials based on proteins, phospholipids and cyclodextrins for food preservation: applications to fresh orange juice and dates”. Collaboration with the Lebanese University, the University Claude Bernard Lyon 1 (LAGEP) and the University of Carthage, Tunisia.
- 2019-2020 : AUF/CNRS Liban SCORE project : “Supramolecular Chelation of Heavy Metals and Radioactive Entities” (SCORE) Chelation supramoléculaire des métaux lourds et d’entités radioactives. (France, Tunisie, Liban).
- 2018-2020 : PHC Galilé (N°39467XJ) : New supramolecular green solvent for VOC abatement. Partenaires :
- Pr Andrea Mele, Politecnico di Milano, Milan, Italie.
- Dr Margarida Costa-Gomes, Laboratoire de Chimie, ENS de Lyon, France.
- 2017-2020 : ADEME GRAINE project « PHYTEO » : The production of essential oils: an eco-innovative way of reconverting historically polluted soils. Transversal project between 3 UCEIV teams, led by the IPCR team (Pr Anissa Hadj-Sahraoui).